BEST3

Barrett’s ESophagus Trial 3 (BEST3)a Trial of a new GP-based test for patients with heartburn symptoms 

Study Objectives:

Early detection of oesophageal cancer has been shown to improve patient outcomes. However, most patients with heartburn (the primary risk factor) are not investigated and most cases of oesophageal cancer present at an advanced stage.

The BEST3 Trial will assess whether the newly-developed CytospongeTM –TFF3 (Trefoil Factor 3) test for patients with reflux symptoms will be effective in increasing the detection of Barrett’s oesophagus in primary care 

 It is hoped that this research will establish whether the CytospongeTM -TFF3 test offers earlier detection and an alternative approach to invasive endoscopy.

You may be eligible to take part if you:

-      Are aged 50 and above

-      Have records of at least six months of prescription for acid-suppressant medication in the last year

If you are registered at one of the practices in the list below, and would like more information about the BEST3 study, please speak to your GP or nurse practitioner.

Beccles Medical Centre

Bridge Road Surgery, Lowestoft

Bungay Medical Practice,

The Castle Partnership, Norwich

Fakenham Medical Practice

Grove Surgery, Thetford

Hingham Surgery

Hoveton and Wroxham Medical Centre

The Humbleyard Practice

Magdalen Medical Practice

Mundesley Medical Centre

Orchard Surgery, Dereham

Rosedale Surgery, Lowestoft

Sheringham Medical Practice

St Stephens Gate Medical Practice

Staithe Surgery, Stalham



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