Functional Strength Training and Movement Performance Therapy for Upper Limb Recovery Early Poststroke—Efficacy, Neural Correlates, Predictive Markers, and Cost-Effectiveness: FAST-INdiCATE Trial.

This multicentre study, coordinated by UEA researchers, investigated whether functional strength training (FST) improves upper limb recovery early post stroke more than movement performance therapy (MPT), and explored neural correlates of clinical improvement in response to both therapies. There was no significant difference in upper limb improvement between FST and MPT and the study found no clinically important association between clinical improvement and change in the neural measures in response to either trial interventions. A substantial variation around the mean change from baseline for both interventions suggests inter-individual differences among stroke survivors in recovery and how they may respond to different physical therapies. Paper is published in Frontiers in Neurology.